NUCLEOTIDE BIOSYNTHESIS (POINT OF COMMONALITY AND DIFFERENCE)
Nucleotide Biosynthesis Points of Commonality an d Difference Learning the pathways of nucleotide synthesis can be a daunting task. You have both purines and pyrimidines to deal with. How best to go about learning these steps is the lesson of this tutorial. The first thing to take note of is that both the purines and the pyrimidines have many points in common in their pathways. Knowing what these are allows you to absorb the information from a comparative perspective as opposed to two separate pathways. Having one to match with the other is the key to making points stick. Lets start by looking at the basic ring systems of purine and pyrimidines. The first thing we note is the size. The pyrimidine ring is smaller and has two fewer nitrogens, and one less carbon. That doesn’t help, except to inform us that a purine ring requires more C and N donors. Next we look at the composition. Lets start with the chemical formulas. Again, we see the major factor is twice the